Use Warning/Keep track of. Ethinyl estradiol may well inhibit the clearance of benzodiazepines that bear oxidation, thereby growing serum concentrations of concomitantly administered benzodiazepines.
If unavoidable, observe people for loss of efficacy unless usually advised in the CYP3A4 substrate prescribing information and facts.
deferasirox will decrease the extent or result of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
These agents really should only be mixed if alternative treatment method options are insufficient. If put together, Restrict the dosages and period of each drug. Take into consideration therapy modification
Reserve concomitant prescribing of these medications in people for whom different procedure choices are inadequate. Limit dosages and durations on the minimum amount required. Comply with people for signs and signs and symptoms of respiratory melancholy and sedation. (see WARNINGS and Safeguards).
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mitotane decreases amounts of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for attainable dosage changes.
aprepitant will boost the level or result of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Actual physical dependence and withdrawal reactions. Estazolam can result in physical dependence and withdrawal reactions, particularly when you proceed to take estazolam for various days to many weeks.
danazol will boost the level or outcome of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
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tazemetostat will lower the extent or effect of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Givinostat is really a weak CYP3A4 inhibitor. Intently keep track of if coadministered with orally administered CYP3A4 delicate substrates for which a little modify in substrate plasma focus might result in really serious toxicities.
Nirmatrelvir/ritonavir Eszopiclone is contraindicated with medicines which might be really depending on CYP3A for clearance and for which elevated concentrations are connected with significant and/or everyday living-threatening reactions.